Fendosal (HP 129): a potent anti-inflammatory and analgesic compound.

Abstract

Fendosal (HP 129) is one of a series of potent non-steroidal anti-inflammatory agents. Fendosal was compared with aspirin in several anti-inflammatory and analgesic bioassay procedures. Results indicate that fendosal has an anti-inflammatory activity 1.4 times greater than does aspirin in carrageenan-induced rat paw edema. Fendosal is 6.9 to 9.5 times more active than aspirin in the prophylactic and therapeutic adjuvant-induced polyarthritis models of chronic inflammation. The analgesic activity of fendosal is considered to be superior to that of aspirin, with the advantage of a prolonged duration of action. The gastric-irritating properties of fendosal are very low in comparison with those of aspirin. Fendosal has a much wider separation of effective and gastric-irritating doses than does aspirin.

• Authors: H B Lassman, J C Wilker, V B Anderson, M N Agnew, R C Allen, W J Novick Jr
• Journal: Agents and actions (Agents Actions) Vol. 8 Issue 3 Pg. 209-17 (Apr 1978) ISSN: 0065-4299 [Print] Switzerland
• PMID: 307337 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Hydroxybenzoates
• Indoles
• Salicylates
• fendosal

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal
• Arthritis, Experimental (physiopathology)
• Edema (physiopathology)
• Female
• Granuloma (physiopathology)
• Hydroxybenzoates
• Indoles
• Rats
• Salicylates