Alogliptin improves survival and health of mice on a high-fat diet.

Abstract

Alogliptin is a commonly prescribed drug treating patients with type 2 diabetes. Here, we show that long-term intervention with alogliptin (0.03% w/w in diet) improves survival and health of mice on a high-fat diet. Alogliptin intervention takes beneficial effects associated with longevity, including increased insulin sensitivity, attenuated functionality decline, decreased organ pathology, preserved mitochondrial function, and reduced oxidative stress. Autophagy activation is proposed as an underlying mechanism of these beneficial effects. We conclude that alogliptin intervention could be considered as a potential strategy for extending lifespan and healthspan in obesity and overweight.

• Authors: Biao Zhu, Yixiang Li, Lingwei Xiang, Jiajia Zhang, Li Wang, Bei Guo, Minglu Liang, Long Chen, Lin Xiang, Jing Dong, Min Liu, Wen Mei, Huan Li, Guangda Xiang
• Journal: Aging cell (Aging Cell) Vol. 18 Issue 2 Pg. e12883 (04 2019) ISSN: 1474-9726 [Electronic] England
• PMID: 30644630 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2019 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

Chemical References

• Piperidines
• Uracil
• alogliptin

Topics

• Animals
• Autophagy (drug effects)
• Diet, High-Fat (adverse effects)
• Disease Models, Animal
• Health
• Liver (drug effects, metabolism, pathology)
• Longevity (drug effects)
• Male
• Mice
• Mice, Inbred C57BL
• Mitochondria, Liver (drug effects, metabolism, pathology)
• Piperidines (pharmacology)
• Survival Rate
• Uracil (analogs & derivatives, pharmacology)