Abstract | BACKGROUND: MATERIALS AND METHODS: We isolated two compounds and identified the structures of them by nuclear magnetic resonance and mass spectrometer. Lung injury was induced by intratracheal instillation with LPS (5 mg/kg). Rats were randomly divided into six groups: Control group; LPS group; 5 mL/kg DEX + LPS group; 6.6 g/kg QBD extract + LPS group; 17.16 mg/kg PGG + LPS group; 7.26 mg/kg EG + LPS group. The effects of compounds on LPS-induced the number of total cells, neutrophils influx, protein leakage, W/D weight ratio and pulmonary histological changes were examined. RESULTS: The results demonstrated that pretreatment with EG and PGG could notably inhibit lung edema and attenuate the pulmonary histological changes (P<0.05). The pretreatment also decreased the number of total cells and polymorphonuclear leukocytes in bronchoalveolar lavage fluid (BALF) (P<0.05). CONCLUSION:
Ethyl gallate and pentagalloylglucose of QBD played a protective role in preventing LPS-induced ALI. The results supported further study of EG and PGG as potential candidates for preventing ALI.
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Authors | Qi Zhang, Jing Nie, Su-Juan Chen, Qiang Li |
Journal | Drug design, development and therapy
(Drug Des Devel Ther)
Vol. 13
Pg. 71-77
( 2019)
ISSN: 1177-8881 [Electronic] New Zealand |
PMID | 30587929
(Publication Type: Journal Article)
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Chemical References |
- Drugs, Chinese Herbal
- Hydrolyzable Tannins
- Lipopolysaccharides
- lipopolysaccharide, E coli O55-B5
- qingwen baidu
- ethyl gallate
- pentagalloylglucose
- Gallic Acid
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Topics |
- Acute Lung Injury
(chemically induced, metabolism, pathology, prevention & control)
- Animals
- Capillary Permeability
(drug effects)
- Disease Models, Animal
- Drugs, Chinese Herbal
(pharmacology)
- Gallic Acid
(analogs & derivatives, pharmacology)
- Hydrolyzable Tannins
(pharmacology)
- Lipopolysaccharides
- Lung
(drug effects, metabolism, pathology)
- Male
- Neutrophil Infiltration
(drug effects)
- Pulmonary Edema
(chemically induced, metabolism, pathology, prevention & control)
- Rats, Sprague-Dawley
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