Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients.

Abstract

Using liquid chromatography - mass spectrometry in combination with derivatisation chemistry we profiled the oxysterol and cholestenoic acid content of cerebrospinal fluid from patients with Alzheimer's disease (n = 21), vascular dementia (n = 11), other neurodegenerative diseases (n = 15, Lewy bodies dementia, n = 3, Frontotemporal dementia, n = 11) and controls (n = 15). Thirty different sterols were quantified and the bile acid precursor 7α,25-dihydroxy-3-oxocholest-4-en-26-oic acid found to be reduced in abundance in cerebrospinal fluid of Alzheimer's disease patient-group. This was the only sterol found to be changed amongst the different groups.

• Authors: William J Griffiths, Jonas Abdel-Khalik, Eylan Yutuc, Gustavo Roman, Margaret Warner, Jan-Åke Gustafsson, Yuqin Wang
• Journal: Free radical biology & medicine (Free Radic Biol Med) Vol. 134 Pg. 42-52 (04 2019) ISSN: 1873-4596 [Electronic] United States
• PMID: 30578919 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

Chemical References

• Bile Acids and Salts
• Biomarkers

Topics

• Alzheimer Disease (cerebrospinal fluid, diagnosis)
• Bile Acids and Salts (cerebrospinal fluid)
• Biomarkers (cerebrospinal fluid)
• Case-Control Studies
• Humans
• Prognosis