Muscle-Specific Kinase Autoimmune Myasthenia Gravis: Report of a Pediatric Case and Literature Review.

Abstract

Myasthenia gravis (MG) with antibodies to the muscle-specific tyrosine kinase (MuSK-MG) receptor is a rare entity. It represents 5 to 8% of all MG patients. Few pediatric cases were reported. Clinical presentation is often atypical. It is characterized by predominant involvement of cranial, bulbar, and axial muscles and early respiratory crises. Myokymia and fasciculation are suggestive of MuSK-MG. The clinical course of patients with MuSK-MG is worse than other types of MG. Responses to standard therapies are variable. We report clinical, neurophysiological, serological, and outcome profile of a Tunisian child with MuSK-MG.

• Authors: Thouraya Ben Younes, Hanene Benrhouma, Hedia Klaa, Rania Ben Aoun, Aida Rouissi, Melika Ben Ahmed, Ichraf Kraoua, Ilhem Ben Youssef-Turki
• Journal: Neuropediatrics (Neuropediatrics) Vol. 50 Issue 2 Pg. 116-121 (04 2019) ISSN: 1439-1899 [Electronic] Germany
• PMID: 30577044 (Publication Type: Case Reports, Journal Article, Review)
• Copyright: Georg Thieme Verlag KG Stuttgart · New York.

Chemical References

• Receptors, Cholinergic
• Steroids
• MUSK protein, human
• Receptor Protein-Tyrosine Kinases

Topics

• Child
• Female
• Humans
• Myasthenia Gravis (blood, diagnosis, drug therapy)
• Receptor Protein-Tyrosine Kinases (blood)
• Receptors, Cholinergic (blood)
• Steroids (administration & dosage)