Medical treatments of reflux esophagitis - Proton pump inhibitors and histamine H2 receptor antagonists -.

Abstract

Inhibitors of gastric acid secretion have been used as main drugs for the treatment of reflux esophagitis. Histamine H2 receptor antagonists (H2RA) and proton pump inhibitors(PPI) are the key drugs in acid inhibitors. Acid inhibition after the administration of H2RA quickly appears and its effect is potent during the nocturnal period. However, their acid inhibitory effect becomes attenuated because of the tolerance phenomenon only after 2-week-long oral administration. On the other hand, potent acid inhibition by PPI continues for long period and it is more potent during the day-time period when gastro-esophageal refluxes frequently occur. From the different characteristics of the two drugs, PPI is used as the first line thera- peutic drug for the treatment of reflux esophagitis, while H2RA is used as a su plementary drug for the patients with nocturnal refluxes.

• Authors: Yoshikazu Kinoshita, Norihisa Ishimura
• Journal: Nihon rinsho. Japanese journal of clinical medicine (Nihon Rinsho) Vol. 74 Issue 8 Pg. 1304-1310 (08 2016) ISSN: 0047-1852 [Print] Japan
• PMID: 30562433 (Publication Type: Journal Article)

Chemical References

• Histamine H2 Antagonists
• Proton Pump Inhibitors

Topics

• Esophagitis, Peptic (drug therapy)
• Gastroesophageal Reflux (drug therapy)
• Histamine H2 Antagonists (therapeutic use)
• Humans
• Proton Pump Inhibitors (therapeutic use)