Objective: To observe the clinical efficacy of nasal
corticosteroids combined with nasal
antihistamine in the treatment of
vasomotor rhinitis. Method: One hundred and twenty
vasomotor rhinitis patients were randomly divided into three groups including
budesonide group,
azelastine group, and
budesonide and
azelastine group with 40 cases in each.
Nasal spray with nasal
corticosteroids and nasal
antihistamines was applied for combined treatment group, while the patients in
budesonide group and
azelastine group were given only nasal
corticosteroids and nasal
antihistamines, respectively. The course lasted 8 weeks, and the clinical efficacy was evaluated with the visual analogue scale (VAS) score and SF-12v2 score. Result: VAS score of the peripheral nasal symptoms of the three groups was significantly decreased
after treatment, and the difference was statistically significant compared with that before treatment (P<0.05). The visual analogue scale of nasal symptoms in the combined treatment group was significantly lower than that in the
budesonide group and the
azelastine group. There was no statistically significant difference between the
budesonide group and the
azelastine group after the treatment on the VAS of the three nasal symptoms. However, compared with before treatment, the difference was statistically significant (P<0.05). The visual analogue scale of nasal symptoms in the combined treatment group was higher than that in the
budesonide group and the
azelastine group, and the difference was statistically significant (P<0.05).
After treatment, there was no significant difference between
budesonide group and
azelastine group (P>0.05). At the same time, the patients in the combined treatment group showed significant efficiency of 47.50% and total efficiency of 90.00%, which were statistically significant compared with
budesonide group (30.00%,75.00%) and
azelastine group (27.50, 70.00%), respectively (P<0.05). But there was no significant difference between
budesonide group and
azelastine group (P>0.05). Conclusion: Nasal
corticosteroids and nasal
antihistamine can effectively relieve the nasal symptoms of
vasomotor rhinitis and improve the quality of life of patients. The effect of nasal
corticosteroids was better than that of nasal
antihistamine. The effect of nasal
corticosteroids combined with nasal
antihistamine was superior to that of single
drug..