Abstract | BACKGROUND: OBJECTIVES: METHODS: In this quasi-experimental study, 130 eligible patients were randomly assigned to intervention (n = 65) and control (n = 65) groups using the four-block method. The intervention group received two capsules of 500 mg and one of 250 mg Zintoma. The control group received three placebo capsules. The severity of patients' PONV was recorded at 0, 2, 6, 12, and 24 hours after surgery using a checklist and a standard VAS instrument. Data were analyzed using t-test, Chi-square test, and LSD Post Hoc test (ANOVA) in SPSS 19. RESULTS: The severity of PONV and vomiting was significantly different between the two groups (P = 0.001) at the above time points. The mean severity of nausea (by VAS) changed in the intervention group from 7.92 ± 1.28 to 0.33 ± 0.67 and in the control group from 8.00 ± 1.20 to 2.11 ± 1.55. The postoperative vomiting was less frequent in the group receiving the Zintoma capsules. The postoperative use of chemical anti- vomiting and nausea drugs was significantly lower in the intervention group than in the placebo group (P = 0.001). CONCLUSIONS: Zintoma capsules can be used as a supportive treatment in the prevention of nausea and vomiting by reducing the incidence rate of PONV.
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Authors | Masoumeh Albooghobeish, Ali Ghomeishi, Sara Adarvishi, Abdolkazem Neisi, Kamran Mahmoodi, Masoomeh Asadi, Fereshteh Amiri, Nasrin Khajeh Ali, Maryam Kouchak, Saba Arya Nasab |
Journal | Anesthesiology and pain medicine
(Anesth Pain Med)
Vol. 8
Issue 5
Pg. e67132
(Oct 2018)
ISSN: 2228-7523 [Print] Netherlands |
PMID | 30533389
(Publication Type: Journal Article)
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