[Hypotensive efficacy of bimatoprost in monotherapy of primary open-angle glaucoma].

Abstract

PURPOSE:

To study the effectiveness of monotherapy with bimatoprost in patients with decompensated intraocular pressure (IOP).

MATERIAL AND METHODS:

90 patients (132 eyes) with stage I-II glaucoma and decompensated IOP previously treated with timolol, latanoprost and travoprost were included in the study. Average IOP at the beginning of the study was 25.4±2.5 mmHg. All patients had their hypotensive medications substituted by bimatoprost. The patients were examined during the initial appointment, as well as after 4 and 12 weeks.

RESULTS:

IOP decrease was highest in the group of patients who had been treated with timolol: initially IOP was 26.2±1.8 mmHg, after 4 weeks - 21.0±2.2 mmHg, after 12 weeks - 20.8±1.9 mmHg (p<0.001). The initial IOP of patients who had been treated with latanoprost was 24.8±2.9 mmHg, 21.8±2.4 mmHg after 4 weeks, and 21.6±2.3 mmHg after 12 weeks (p<0.001). Patients who had been treated with travoprost had 25.6±2.2 mmHg initially, 23.0±2.5 mmHg after 4 weeks, and 23.2±2.6 mmHg after 12 weeks (p<0.001). By the end of the study IOP has decreased by 5.4, 3.2 and 2.4 mmHg in the groups of patients who had been treated with timolol, latanoprost and travoprost, respectively.

CONCLUSION:

Bimatoprost can be used as monotherapy if another hypotensive drug in monotherapy is insufficient for IOP compensation.

• Authors: S Yu Petrov, I V Kozlova, V S Zinina, A V Volzhanin, M V Kravchik
• Journal: Vestnik oftalmologii (Vestn Oftalmol) 2018 Vol. 134 Issue 5. Vyp. 2 Pg. 208-214 ISSN: 0042-465X [Print] Russia (Federation)
• Vernacular Title: Gipotenzivnaia éffektivnost' bimatoprosta v monoterapii pervichnoĭ otkrytougol'noĭ glaukomy.
• PMID: 30499519 (Publication Type: Journal Article)

Chemical References

• Antihypertensive Agents
• Prostaglandins F, Synthetic
• Latanoprost
• Timolol
• Bimatoprost

Topics

• Antihypertensive Agents (therapeutic use)
• Bimatoprost (therapeutic use)
• Glaucoma, Open-Angle
• Humans
• Intraocular Pressure
• Latanoprost
• Prostaglandins F, Synthetic
• Timolol
• Treatment Outcome