Long-Term Parathyroid Hormone 1-34 Replacement Therapy in Children with Hypoparathyroidism.

Abstract

OBJECTIVE:

To determine whether multiple daily injections of parathyroid hormone (PTH) 1-34 are safe and effective as long-term therapy for children with hypoparathyroidism.

STUDY DESIGN:

Linear growth, bone accrual, renal function, and mineral homeostasis were studied in a long-term observational study of PTH 1-34 injection therapy in 14 children.

METHODS:

Subjects were 14 children with hypoparathyroidism attributable to autoimmune polyglandular syndrome type 1 (N = 5, ages 7-12 years) or calcium receptor mutation (N = 9, ages 7-16 years). Mean daily PTH 1-34 dose was 0.75 ± 0.15 µg/kg/day. Treatment duration was 6.9 ± 3.1 years (range 1.5-10 years). Patients were evaluated semiannually at the National Institutes of Health Clinical Center.

RESULTS:

Mean height velocity and lumbar spine, whole body, and femoral neck bone accretion velocities were normal throughout the study. In the first 2 years, distal one-third radius bone accrual velocity was reduced compared with normal children (P < .003). Serum alkaline phosphatase correlated with PTH 1-34 dose (P < .006) and remained normal (235.3 ± 104.8 [SD] U/L, N: 51-332 U/L). Mean serum and 24-hour urine calcium levels were 2.05 ± 0.11 mmol/L (N: 2.05-2.5 mmol/L) and 6.93 ± 1.3 mmol/24 hour (N: 1.25-7.5 mmol/24 hour), respectively-with fewer high urine calcium levels vs baseline during calcitriol and calcium treatment (P < .001). Nephrocalcinosis progressed in 5 of 12 subjects who had repeated renal imaging although renal function remained normal.

CONCLUSIONS:

Twice-daily or thrice-daily subcutaneous PTH 1-34 injections provided safe and effective replacement therapy for up to 10 years in children with hypoparathyroidism because of autoimmune polyglandular syndrome type 1 or calcium receptor mutation.

• Authors: Karen K Winer, Andrea Kelly, Alicia Johns, Bo Zhang, Karen Dowdy, Lauren Kim, James C Reynolds, Paul S Albert, Gordon B Cutler Jr
• Journal: The Journal of pediatrics (J Pediatr) Vol. 203 Pg. 391-399.e1 (12 2018) ISSN: 1097-6833 [Electronic] United States
• PMID: 30470382 (Publication Type: Journal Article, Observational Study, Research Support, N.I.H., Intramural)
• Copyright: Published by Elsevier Inc.

Chemical References

• CASR protein, human
• Parathyroid Hormone
• Receptors, Calcium-Sensing
• Vitamin D
• Phosphorus
• Creatinine
• Calcium

Topics

• Adolescent
• Body Height (drug effects)
• Calcinosis
• Calcium (blood, urine)
• Child
• Creatinine (urine)
• DNA Mutational Analysis
• Female
• Homeostasis
• Hormone Replacement Therapy
• Humans
• Hypoparathyroidism (drug therapy)
• Kidney Function Tests
• Linear Models
• Male
• Nephrocalcinosis (metabolism)
• Parathyroid Hormone (administration & dosage, therapeutic use)
• Phosphorus (blood, urine)
• Polyendocrinopathies, Autoimmune (genetics)
• Receptors, Calcium-Sensing (genetics)
• Treatment Outcome
• Vitamin D (blood)