Bayesian Optimization of Asynchronous Distributed Microelectrode Theta Stimulation and Spatial Memory.

Abstract

There is a great need for an electrical stimulation therapy to treat medication-resistant, surgically ineligible epileptic patients that successfully reduces seizure incidence with minimal side effects. Critical to advancing such therapies will be identifying the trade-offs between therapeutic efficacy and side effects. One novel treatment developed in the tetanus toxin rat model of mesial temporal lobe epilepsy, asynchronous distributed microelectrode stimulation (ADMETS) in the hippocampus has been shown to significantly reduce seizure frequency. However, our results have demonstrated that ADMETS has a negative effect on spatial memory that scales with the amplitude of stimulation. Given the high dimensional space of possible stimulation parameters, it is difficult to construct a mapping from variations in stimulation to behavioral effect. In this project, we present a novel, principled approach using closed-loop Bayesian optimization to tune stimulation that successfully maximize a desired objective - performance on a spatial memory assay.

• Authors: Omer Ashmaig, Mark Connolly, Robert E Gross, Babak Mahmoudi
• Journal: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference (Annu Int Conf IEEE Eng Med Biol Soc) Vol. 2018 Pg. 2683-2686 (Jul 2018) ISSN: 2694-0604 [Electronic] United States
• PMID: 30440959 (Publication Type: Journal Article)

Topics

• Animals
• Bayes Theorem
• Epilepsy, Temporal Lobe (therapy)
• Hippocampus
• Microelectrodes
• Rats
• Seizures (therapy)
• Spatial Memory
• Theta Rhythm