Icodextrin is Associated with a Lower Risk of Stroke in Peritoneal Dialysis Patients.

Abstract

BACKGROUND/AIMS:

This study investigated whether peritoneal dialysis (PD) patients using icodextrin were at a reduced risk of stroke.

METHODS:

From Taiwan National Health Insurance data, it was found that there were 6,796 new end-stage renal disease patients undergoing dialysis between 2005 and 2011. We compared the risk of stroke between PD patients with or without icodextrin treatment. The follow-up period began from the date of PD initiation to the end of 2011. The time-dependent Cox proportional hazards regression models were used to analyze the risk of stroke.

RESULTS:

Among PD patients, the icodextrin users had both a lower incidence and risk of stroke than icodextrin non-users (incidence: 22.4 vs. 25.2/1,000 person-years) with an adjusted hazard ratio of 0.76 (95% CI 0.63-0.93). The results were similar in models considering death a competing risk (overall: adjusted subhazard ratio [SHR] 0.78, 95% CI 0.63-0.94). Icodextrin users also had a lower risk of ischemic stroke with or without considering death a competing risk (adjusted SHR 0.71, 95% CI 0.57-0.89 and adjusted HR 0.74, 95% CI 0.59-0.93, respectively), compared to non-users.

CONCLUSION:

The use of icodextrin is associated with a lower incidence and risk of stroke in PD patients.

• Authors: Chih-Wei Chiu, Tsung-Hsun Tsai, Cheng-Li Lin, Tzung-Hai Yen, I-Kuan Wang, Chi-Yuan Li
• Journal: Nephron (Nephron) Vol. 141 Issue 2 Pg. 112-118 ( 2019) ISSN: 2235-3186 [Electronic] Switzerland
• PMID: 30423579 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2018 S. Karger AG, Basel.

Chemical References

• Dialysis Solutions
• Icodextrin

Topics

• Aged
• Dialysis Solutions (adverse effects)
• Female
• Humans
• Icodextrin (adverse effects)
• Incidence
• Middle Aged
• Peritoneal Dialysis (adverse effects)
• Proportional Hazards Models
• Risk Factors
• Risk Reduction Behavior
• Stroke (etiology)
• Taiwan