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IL-1 Blockade Reduces Inflammation in Pulmonary Arterial Hypertension and Right Ventricular Failure: A Single-Arm, Open-Label, Phase IB/II Pilot Study.

AuthorsCory R Trankle, Justin M Canada, Dinesh Kadariya, Roshanak Markley, Horacio Medina De Chazal, Janet Pinson, Adam Fox, Benjamin W Van Tassell, Antonio Abbate, Daniel Grinnan
JournalAmerican journal of respiratory and critical care medicine (Am J Respir Crit Care Med) Vol. 199 Issue 3 Pg. 381-384 (02 01 2019) ISSN: 1535-4970 [Electronic] United States
PMID30418047 (Publication Type: Clinical Trial, Phase I, Clinical Trial, Phase II, Letter, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References
  • Interleukin 1 Receptor Antagonist Protein
  • Interleukin-1
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Heart Failure (complications)
  • Humans
  • Hypertension, Pulmonary (complications)
  • Inflammation (complications, prevention & control)
  • Interleukin 1 Receptor Antagonist Protein (administration & dosage)
  • Interleukin-1 (antagonists & inhibitors)
  • Male
  • Middle Aged
  • Pilot Projects
  • Pulmonary Artery
  • Ventricular Dysfunction, Right (complications)
  • Ventricular Function, Right

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