[Efficacy and safety of immunotherapy in dust mites andalternaria multi-sensitized allergic rhinitis patients].

Abstract

Objective:The aim of this study is to evaluate the efficacy and safety of immunosuppression in patients with allergic rhinitis with multiple sensitization of dust mites and Alternaria.Method:An open, label random parallel controlled clinical study was conducted. Sixty dust mites and alternaria multi-sensitized allergic rhinitis patients were enrolled and randomized into immunotherapy group and medication group.Evaluation indicators included symptom scores, medication scores,symptom medication combined scores,RQLQ and serum allergen-specific IgE.In immunotherapy group, side effects were also observed and recorded.Result:After 24 months of treatment, all the scores were significantly lower than baseline,in both immunotherapy group and medication group.The scores of immunotherapy group were significantly lower than those of the medication group. Only local side effects were observed in immunotherapy group,without any systemic side effects and anaphylaxis.Conclusion: Mixed immunotherapy with dust mites and alternaria was effective and safe in allergic rhinitis patients and it had better curative effect than medication.

• Authors: W J Li, N Huang, Y Q Yang, R Zhang, D X Ma, S C Zhang, R F Zhu
• Journal: Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery (Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi) Vol. 32 Issue 21 Pg. 1623-1626 (Nov 2018) ISSN: 2096-7993 [Print] China
• PMID: 30400684 (Publication Type: English Abstract, Journal Article)
• Copyright: Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.