Factors Affecting Relapse and Remission in Behçet's Uveitis Treated with Interferon Alpha2a.

Abstract

PURPOSE:

To investigate factors affecting relapse and remission in patients with Behçet uveitis (BU) in the context of using the interferon alpha2a (IFNα2a) therapy.

METHODS:

Clinical records were reviewed of 32 patients (totaling 54 eyes) presenting with severe BU who had been treated with IFNα2a therapy. Factors influencing relapsing-remitting course of BU during IFNα2a therapy and after the cessation of the agent were evaluated. Possible affecting factors of recurrence were age, gender, duration of the Behçet disease, time elapsed before starting the drug, number of relapses before the starting of IFNα2a, laterality, and presence of panuveitis.

RESULTS:

Thirty patients (93.7%) responded to IFNα2a therapy. Annual attack rate before and after IFNα2a treatment was determined to be 4.03 ± 3.19 (attack per year) and 0.58 ± 1.07, respectively (P < 0.001). In univariable statistical evaluation, women tended to have a lower relapse risk than men. Multivariable analyses showed that age was the major factor determining relapse rate, while the effect of gender was not statistically significant (P = 0.196). The other probable influencing factors were not found to be statistically significant (P > 0.05). Increase in visual acuity observed during last examination compared to initial examination was determined to be statistically significant (P = 0.018).

CONCLUSIONS:

Even if the female gender was evaluated as a good prognostic factor in univariable analyses, it was not assessed as an effective prognostic factor in multivariable analyses. Being aged may be regarded a good prognostic factor on the relapsing-remitting course of patients with BU who were treated with IFNα2a therapy.

• Authors: Hande Celiker, Haluk Kazokoglu, Haner Direskeneli
• Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics (J Ocul Pharmacol Ther) 2019 Jan/Feb Vol. 35 Issue 1 Pg. 58-65 ISSN: 1557-7732 [Electronic] United States
• PMID: 30359208 (Publication Type: Journal Article)

Chemical References

• Immunosuppressive Agents
• Interferon alpha-2
• Ophthalmic Solutions

Topics

• Adult
• Behcet Syndrome (diagnosis, drug therapy)
• Female
• Humans
• Immunosuppressive Agents (administration & dosage, adverse effects, therapeutic use)
• Inflammation (diagnosis, drug therapy)
• Interferon alpha-2 (administration & dosage, adverse effects, therapeutic use)
• Male
• Middle Aged
• Multivariate Analysis
• Ophthalmic Solutions (administration & dosage, adverse effects, therapeutic use)
• Treatment Outcome
• Uveitis (diagnosis, drug therapy)
• Young Adult