Abstract | PURPOSE: METHODS: This was a retrospective review of 14 eyes of 8 patients with Reis-Bücklers' corneal dystrophy that underwent surgical peeling with a spatula of the epithelium and subepithelial membrane present in Reis-Bücklers' corneal dystrophy, with subsequent sequential customized therapeutic keratectomy featuring a multi-step approach with sequential, repeated customized excimer laser photoablations alternating with repeat intraoperative topographies to monitor and progressively reduce corneal irregularities. RESULTS: At the last follow-up of 5.09 ± 4.67 years (range: 0.29 to 12.87 years), mean corrected distance visual acuity improved from 20/50 (range: 20/630 to 20/30) to 20/25 (range: 20/20 to 20/40) (P < .01), whereas mean refraction changed from -0.29 ± 1.91 diopters (D) sphere and -0.75 ± 0.81 D cylinder preoperatively to 1.25 ± 2.10 D sphere and -1.08 ± 0.53 D cylinder postoperatively. Mean central keratometry values changed minimally from 42.67 ± 2.26 D preoperatively to 42.65 ± 2.30 D postoperatively. Coma significantly decreased from 0.60 ± 0.40 to 0.35 ± 0.28 μm (P < .05), whereas total higher order aberrations, spherical aberration, and trefoil remained stable. No patient underwent corneal transplantation. Disease recurrence required re-treatment using the same protocol in 14.28% of eyes (n = 2) for a mean of 5.86 ± 0.31 years (range: 5.64 to 6.08 years) after initial surgery. CONCLUSIONS: Five years after sequential customized therapeutic keratectomy, most eyes with Reis-Bücklers' corneal dystrophy showed improved visual acuity, stable refraction, and improved or stable higher order aberrations. [J Refract Surg. 2018;34(10):682-688.].
|
Authors | Paolo Vinciguerra, Riccardo Vinciguerra, J Bradley Randleman, Ingrid Torres, Emanuela Morenghi, Fabrizio I Camesasca |
Journal | Journal of refractive surgery (Thorofare, N.J. : 1995)
(J Refract Surg)
Vol. 34
Issue 10
Pg. 682-688
(Oct 01 2018)
ISSN: 1081-597X [Print] United States |
PMID | 30296329
(Publication Type: Journal Article)
|
Copyright | Copyright 2018, SLACK Incorporated. |
Topics |
- Adult
- Cornea
(physiopathology, surgery)
- Corneal Dystrophies, Hereditary
(physiopathology, surgery)
- Female
- Follow-Up Studies
- Humans
- Lasers, Excimer
(therapeutic use)
- Male
- Middle Aged
- Photorefractive Keratectomy
(methods)
- Refraction, Ocular
(physiology)
- Retrospective Studies
- Treatment Outcome
- Visual Acuity
(physiology)
- Young Adult
|