[CORRECTION OF INTRAABDOMINAL PRESSURE IN RATS IN AN ACUTE PANCREATITIS, USING INFUSION OF MYORELAXANT OF A DURABLE ACTION PIPECURONIUM BROMIDE].

Abstract

Impact of a durable action of myorelaxant pipecuronium bromide on intraabdominal pressure (IAP) in rats in experimentally simulated acute peritonitis was studied. In the rats in purulent pancreatitis, іnduced by L-аrginin, IAP was in 4,5 times high (p < 0.001), than in intact laboratory animals. Pipecuronium bromide have lowered IAP by 33.4%, witnessing efficacy of application of myorelaxants in treatment of intraabdominal hypertension in purulent pancreatitis.

• Authors: A S Morgun, A I Sukhodolya, O V Kabanov, S A Sukhodolya, M Falaleyeva, T V Beregova
• Journal: Klinichna khirurhiia (Klin Khir) 2017 Issue 1 Pg. 67-9 ISSN: 0023-2130 [Print] Ukraine
• PMID: 30272925 (Publication Type: Journal Article)

Chemical References

• Neuromuscular Nondepolarizing Agents
• Pipecuronium
• Arginine

Topics

• Acute Disease
• Animals
• Animals, Outbred Strains
• Arginine (administration & dosage)
• Injections, Intramuscular
• Injections, Intraperitoneal
• Intra-Abdominal Hypertension (chemically induced, complications, drug therapy, physiopathology)
• Neuromuscular Nondepolarizing Agents (pharmacology)
• Peritonitis (chemically induced, complications, physiopathology)
• Pipecuronium (pharmacology)
• Rats