Analysis of familial factors in bipolar affective illness.

Abstract	Familial transmission of affective illness was studied using a family interview and family history method in a group of 35 bipolar manic-depressive patients. Morbidity risk for bipolar and unipolar affective illness in first-degree relatives is approximately 30% in this population. Probands with a positive family history for bipolar illness have a significantly greater risk for alcoholism in first-degree relatives. Four cases of father-to-son transmission are reported. Linkage of color vision deficiency or Xga blood group and affective illness within families could not be substantiated in our sample. We discuss evidence regarding the mode of transmission of affective illness.
Authors	G F Johnson, M M Leeman
Journal	Archives of general psychiatry (Arch Gen Psychiatry) Vol. 34 Issue 9 Pg. 1074-83 (Sep 1977) ISSN: 0003-990X [Print] United States
PMID	302694 (Publication Type: Journal Article)
Chemical References	Blood Group Antigens
Topics	Adult Age Factors Aged Alcoholism (genetics) Bipolar Disorder (genetics) Blood Group Antigens Color Vision Defects (genetics) Depression (genetics) Female Humans Male Mental Disorders (genetics) Middle Aged Pedigree Risk Sex Chromosomes Sex Ratio

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