Abstract | AIM: METHODS: A cross sectional study was designed to estimate the levels of MIP-1α and MCP-1 in whole unstimulated saliva from 75 patients who were divided into healthy (Group 1, n = 25), gingivitis (Group 2, n = 25) and chronic generalized periodontitis (Group 3, n = 25). MIP-1α and MCP-1 levels were estimated by using ELISA and were correlated with clinical parameters. ROC curve analysis was done to determine the sensitivity and specificity of these biomarkers in distinguishing periodontal disease from health. RESULTS: Both the biomarkers were detected in all the saliva samples. There was a statistically significant difference in the concentration of both the analytes in Group 3 and Group 2 compared with Group 1 (p < 0.001). ROC curve analysis showed 100% sensitivity and specificity for MIP-1α and MCP-1 in discriminating periodontitis from health. For discriminating gingivitis from health, MIP-1α had a higher sensitivity and specificity (100% & 88% respectively) compared to MCP-1(84.1% & 80% respectively). CONCLUSION:
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Authors | K J Nisha, Aparnna Suresh, A Anilkumar, Shyam Padmanabhan |
Journal | The Saudi dental journal
(Saudi Dent J)
Vol. 30
Issue 4
Pg. 292-298
(Oct 2018)
ISSN: 1013-9052 [Print] Saudi Arabia |
PMID | 30202165
(Publication Type: Journal Article)
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