Abstract | OBJECTIVE: Neonatal meningitis caused by Escherichia coli results in significant mortality and neurological disabilities, with few effective treatments. Recently, we demonstrated that human umbilical cord blood-derived mesenchymal stem cell (hUCB-MSC) transplantation attenuated E. coli-induced severe pneumonia, primarily by reducing inflammation and enhancing bacterial clearance. This study aimed to determine whether intraventricular transplantation of hUCB-MSCs attenuated the brain injury in E. coli meningitis in newborn rats. METHODS: RESULT:
Meningitis modeling induced robust proliferation of E. coli in the cerebrospinal fluid and increased mortality in rat pups, and MSC transplantation significantly reduced this bacterial growth and the mortality rate. Impaired sensorimotor function in the meningitis rats was ameliorated by MSCs injection. MSCs transplantation also attenuated meningitis caused brain injury including cerebral ventricular dilatation, brain cell death, reactive gliosis, and inflammatory response. CONCLUSION: Intraventricular transplantation of hUCB-MSCs significantly improved survival and attenuated the brain injury via anti-inflammatory and antibacterial effects in experimental neonatal E. coli meningitis.
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Authors | So Yoon Ahn, Yun Sil Chang, Young Eun Kim, Se In Sung, Dong Kyung Sung, Won Soon Park |
Journal | Pediatric research
(Pediatr Res)
Vol. 84
Issue 5
Pg. 778-785
(11 2018)
ISSN: 1530-0447 [Electronic] United States |
PMID | 30188499
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cytokines
- Inflammation Mediators
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Topics |
- Animals
- Animals, Newborn
- Body Weight
- Brain Injuries
(diagnostic imaging, etiology, metabolism, prevention & control)
- Colony Count, Microbial
- Cytokines
(metabolism)
- Escherichia coli
(isolation & purification)
- Inflammation Mediators
(metabolism)
- Magnetic Resonance Imaging
- Meningitis, Escherichia coli
(complications, diagnostic imaging, metabolism, therapy)
- Mesenchymal Stem Cell Transplantation
- Rats
- Rats, Sprague-Dawley
- Survival Rate
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