Fresh frozen plasma (Octaplas) and topical heparin in the management of ligneous conjunctivitis.

Abstract

Ligneous conjunctivitis is a rare form of chronic recurrent membranous conjunctivitis with reduced plasminogen activity. It is characterized by the formation of characteristic firm ("woody") membranes on the tarsal conjunctiva. Similar lesions may occur on other mucous membranes. When treated with local excision, ligneous conjunctivitis is invariably associated with recurrences. Various therapeutic modalities, including topical heparin, cyclosporine, fresh frozen plasma (FFP), plasminogen, and amniotic membrane transplantation have been reported to reduce postoperative recurrences. We present 2 cases of recurrent ligneous conjunctivitis in children successfully managed with surgical excision under cover of FFP transfusion, amniotic membrane grafting, and combined with concomitant postoperative administration of topical heparin, steroids.

• Authors: Patrick Watts, Shahab H Agha, Maha Mameesh, Phillip Conor, Anuradha Ganesh, Abdullah Al-Mujaini, Hugh Jewsbury, Anil Pathare, Abdulhakim Al-Rawas
• Journal: Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus (J AAPOS) Vol. 23 Issue 1 Pg. 42-45.e1 (02 2019) ISSN: 1528-3933 [Electronic] United States
• PMID: 30165199 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2018 American Association for Pediatric Ophthalmology and Strabismus. All rights reserved.

Chemical References

• Anticoagulants
• Plasminogen
• Heparin

Topics

• Administration, Topical
• Anticoagulants (administration & dosage)
• Child
• Conjunctivitis (complications, etiology, therapy)
• Female
• Heparin (administration & dosage)
• Humans
• Infant
• Male
• Plasma
• Plasminogen (deficiency)
• Skin Diseases, Genetic (complications)
• Treatment Outcome