Collagenase Clostridium histolyticum for the Treatment of Distal Interphalangeal Joint Contractures in Dupuytren Disease.

Abstract

PURPOSE:

To explore the efficacy of injectable collagenase Clostridium histolyticum (CCH) in distal interphalangeal (DIP) joint contractures in Dupuytren disease.

METHODS:

A retrospective review was conducted for patients with DIP joint contractures treated with CCH. Baseline contracture and posttreatment residual contracture were recorded. The primary end point was achievement of 0° to 5° of residual contracture 30 days postmanipulation. Recurrence and adverse events are also reported.

RESULTS:

Twenty-one patients were treated with collagenase for DIP joint contractures and had a mean follow-up of 2.6 months. Seventeen of 21 patients reached the primary end point of less than 5° residual flexion contracture. Eleven of 21 patients experienced an adverse event, most commonly bruising and edema. No serious complications such as neurovascular injuries or tendon ruptures were recorded. Two patients had recurrence of disease.

CONCLUSIONS:

Injection with CCH is an option for the treatment of DIP joint contractures in Dupuytren disease.

TYPE OF STUDY/LEVEL OF EVIDENCE:

Therapeutic IV.

• Authors: Timothy T Fei, Evan Chernoff, Nathan A Monacco, David E Komatsu, Samantha Muhlrad, Steven P Sampson, Lawrence C Hurst, Alexander B Dagum
• Journal: The Journal of hand surgery (J Hand Surg Am) Vol. 44 Issue 5 Pg. 417.e1-417.e4 (May 2019) ISSN: 1531-6564 [Electronic] United States
• PMID: 30146387 (Publication Type: Journal Article)
• Copyright: Copyright © 2019 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.

Chemical References

• Microbial Collagenase

Topics

• Aged
• Arthrometry, Articular
• Clostridium histolyticum
• Dupuytren Contracture (therapy)
• Female
• Finger Joint
• Follow-Up Studies
• Humans
• Injections, Intra-Articular
• Male
• Microbial Collagenase (therapeutic use)
• Retrospective Studies