Background: Perineal
trauma is a common problem that may affect women during vaginal delivery; this
trauma can be either spontaneous (tear) or intentional (
episiotomy). When repair of perineal
trauma is required, adequate
analgesics must be obtained. Topical products as
lidocaine-prilocaine (
EMLA) cream is one of the suggested methods, but still there is lack of evidence with regard to its efficacy and safety.Objective: The aim of this review is to assess the evidence of utilizing
EMLA cream in comparison to local perineal
infiltration anesthesia for
pain control during perineal repair after vaginal delivery.Data sources: Medline, Embase, Dynamed Plus, ScienceDirect, TRIP database, ClinicalTrials.gov and the Cochrane Library were searched electronically from January 2006 to May 2018 for studies investigating the effect of
lidocaine-prilocaine cream in relieving
pain during repair of perineal
trauma.Methods of study selection: All randomized controlled trials assessing effect of
lidocaine-prilocaine cream versus local
infiltration anesthesia in relieving
pain during repair of perineal
trauma were considered for this meta-analysis. Fifteen studies were identified of which four studies deemed eligible for this review. Quality and risk of bias assessment was performed for all studies.Data extraction: Two researchers independently extracted the data from the individual articles and entered into RevMan software. The weighted mean difference (WMD) and 95% confidence interval (CI) was calculated. Statistical heterogeneity between studies was assessed by the Higgins chi-square and (I2) statistics. When heterogeneity was significant, a random-effects model was used for meta-analysis. Otherwise, the fixed effect meta-analysis was used when there was no significant heterogeneity.Results: Pooled analysis of result in "
pain score" was insignificant between the two groups (WMD -1.11; 95% CI (-2.55 to 0.33); p = .13). Furthermore, the use of additional
analgesia showed no statistically significant difference between the two groups (WMD 1.34; 95% CI (0.66-2.71), p = .42). Regarding patient satisfaction, an overall analysis of three studies showed significant results favoring
EMLA cream group users (WMD 4.65; 95% CI (1.96-11.03), p = .0005). The pooled analysis of the outcome "duration of repair" showed the significantly shorter duration of repair in
EMLA cream users (n = 92) than local
infiltration anesthesia (n = 95) (1.72 min; 95% CI (-2.76 to -0.67), p = .001).Conclusions: This meta-analysis suggests that topical
lidocaine-prilocaine cream gives comparable results in reducing
pain during perineal repair after vaginal delivery.