Gonadotropin-Releasing Hormone Agonist Corrects Defective Mini-Puberty in Boys with Cryptorchidism: A Prospective Randomized Study.

Abstract

INTRODUCTION:

This prospective study investigated the efficacy of a gonadotropin-releasing hormone agonist (LH-RHa) in restoring defective mini-puberty.

MATERIALS AND METHODS:

Boys with isolated bilateral cryptorchidism and defective mini-puberty were randomly divided into two groups. The "surgery only" group underwent a second orchidopexy without hormonal treatment (control). The "LH-RHa" group received LH-RHa therapy followed by a second orchidopexy. The number of Ad spermatogonia and the total germ cell count per tubule (S/T) were analyzed.

RESULTS:

Five boys were included in each arm. In the LH-RHa group, the median S/T increased from 0.11 to 0.42, p=0.04. In the surgery only group, the median S/T did not change. In the surgery only group, none of the testes had Ad spermatogonia. In contrast, in the LH-RHa group, all testes completed the transition from gonocytes to Ad spermatogonia (p=0.008).

CONCLUSIONS:

Treatment with LH-RHa was effective in rescuing defective mini-puberty in boys with bilateral cryptorchidism.

• Authors: Beata Vincel, Gilvydas Verkauskas, Vytautas Bilius, Darius Dasevicius, Dalius Malcius, Birute Jones, Faruk Hadziselimovic
• Journal: BioMed research international (Biomed Res Int) Vol. 2018 Pg. 4651218 ( 2018) ISSN: 2314-6141 [Electronic] United States
• PMID: 30065939 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Gonadotropin-Releasing Hormone

Topics

• Child
• Cryptorchidism (drug therapy)
• Gonadotropin-Releasing Hormone (therapeutic use)
• Humans
• Infertility, Male
• Male
• Prospective Studies
• Sexual Maturation