Immunoglobulin-induced aseptic meningitis: a case report.

Abstract

BACKGROUND:

Immunoglobulin associated meningitis is a rare disease that mimics infectious meningitis. This is, to our knowledge, the first case of Immunoglobulin-associated meningitis described in a patient with Systemic Lupus Erythematosus and hypogammaglobulinemia secondary to Rituximab.

CASE PRESENTATION:

A 46-year-old female with a past medical history of Systemic Lupus Erythematosus, presented with meningismus 36 h after first infusion of intravenous immunoglobulin. The cerebrospinal fluid analysis showed neutrophilic pleocytosis and hyperproteinorrachia. All microbiological tests were negative. The patient recovered remarkably fast without sequela after just five days of antibiotic therapy.

CONCLUSION:

Systemic Lupus Erythematosus is a well-documented risk factor for aseptic meningitis associated with other drugs. Possibly, it is also a risk factor for Immunoglobulin associated meningitis. This diagnosis, although rare, should be considered in patients receiving Immunoglobulin since it is a self-limited condition and treatment is supportive.

• Authors: Luísa Graça, Joana Alves, João Nuak, António Sarmento
• Journal: BMC neurology (BMC Neurol) Vol. 18 Issue 1 Pg. 97 (Jul 17 2018) ISSN: 1471-2377 [Electronic] England
• PMID: 30016937 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunologic Factors
• Rituximab

Topics

• Agammaglobulinemia (chemically induced, complications, diagnosis)
• Female
• Humans
• Immunologic Factors (adverse effects)
• Lupus Erythematosus, Systemic (complications, drug therapy)
• Meningitis, Aseptic (diagnosis, etiology, physiopathology)
• Middle Aged
• Risk Factors
• Rituximab (adverse effects)