Abstract |
Nano-delivery systems have gained remarkable recognition for targeted delivery of therapeutic payload, reduced off-target effects, and improved biopharmaceutical profiles of drugs. Therefore, we aimed to fabricate polymeric nanoparticles (NPs) to deliver tacrolimus (TCS) to deeper layers of the skin in order to alleviate its systemic toxicity and improved therapeutic efficacy against atopic dermatitis (AD). To further optimize the targeting efficiency, TCS-loaded NPs were coated with hyaluronic acid (HA). Following the various physicochemical optimizations, the prepared HA-TCS-CS-NPs were tested for in vitro drug release kinetics, drug permeation across the stratum corneum, percentage of drug retained in the epidermis and dermis, and anti-AD efficacy. Results revealed that HA-TCS-CS-NPs exhibit sustained release profile, promising drug permeation ability, improved skin retention, and pronounced anti-AD efficacy. Conclusively, we anticipated that HA-based modification of TCS-CS-NPs could be a promising therapeutic approach for rationalized management of AD, particularly in children as well as in adults having steroid phobia.
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Authors | Fan Zhuo, Mohammed A S Abourehab, Zahid Hussain |
Journal | Carbohydrate polymers
(Carbohydr Polym)
Vol. 197
Pg. 478-489
(Oct 01 2018)
ISSN: 1879-1344 [Electronic] England |
PMID | 30007638
(Publication Type: Journal Article)
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Copyright | Copyright © 2018 Elsevier Ltd. All rights reserved. |
Chemical References |
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Topics |
- Animals
- Dermatitis, Atopic
(drug therapy, pathology)
- Dose-Response Relationship, Drug
- Drug Delivery Systems
- Humans
- Hyaluronic Acid
(administration & dosage, chemistry, pharmacology)
- Kinetics
- Mice
- Nanoparticles
(chemistry)
- Particle Size
- Skin
(drug effects)
- Surface Properties
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