Abstract | BACKGROUND: OBJECTIVE: The aim of this study is to assess the effectiveness of LTNIV in COPD patients requiring frequent hospital admissions and NIV support for AHRF. MATERIALS AND METHODS: A prospective cohort study including 120 patients having survived an admission requiring NIV support for AHRF due to COPD, with a history of ≥3 similar episodes in the past year. Patients were advised LTNIV (30) with standard treatment, or (90) standard treatment alone. Both groups were followed up for 1 year. Among non-NIV group 10 died, and 8 lost follow-up, whereas two died in NIV group. The primary endpoint was death. Data of remaining 100 patients were analyzed for other objectives-number of readmissions, AHRF, Intensive Care Unit (ICU)/ ventilator requirement, dyspnea, quality of life, exercise tolerance, lung function, and arterial blood gases. RESULTS: LTNIV group had 40% reduction in mortality (6.6% vs. 11.1%). There was significant reduction in number of hospital admissions (28.6% vs. 84.7%: P <0.05), ICU admissions (7.1% vs. 56.9%: P = 0.01), ventilator requirement (3.6% vs. 30.6%: P = 0.003), AHRF (7.1% vs. 48.6%: P = 0.000) and improvement in partial arterial CO2 pressure (39.8 ± 2.1 vs. 57.03 ± 3.7 mmHg) and severe respiratory insufficiency score (P < 0.05) among LTNIV group, but no significant change in lung function and exercise tolerance. CONCLUSION: Patients tolerated LTNIV well and had a better outcome compared to those without NIV. LTNIV may be considered in patients with recurrent AHRF.
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Authors | K P Suraj, E Jyothi, R Rakhi |
Journal | Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine
(Indian J Crit Care Med)
Vol. 22
Issue 6
Pg. 397-401
(Jun 2018)
ISSN: 0972-5229 [Print] India |
PMID | 29962738
(Publication Type: Journal Article)
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