Perinuclear Antineutrophil Cytoplasmic Antibody Positive Glomerulonephritis in a Case of Limited Cutaneous Scleroderma.

Abstract

Antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis in a patient of scleroderma is very rare. Very few cases have been reported in English literature. We report a case of a 58-year-old male with long-standing limited cutaneous scleroderma (Scl-70 positive) presenting with normotensive scleroderma renal crisis. Perinuclear ANCA with antimyeloperoxidase antibody was found to be strongly positive. Renal biopsy showed pauci immune-necrotizing crescentic glomerulonephritis. We believe that this case report will be helpful in understanding clinical features of normotensive ANCA-associated glomerulonephritis in scleroderma patients.

• Authors: H Vora, B Kulkarni, S Singh, N Kulkarni
• Journal: Indian journal of nephrology (Indian J Nephrol) 2018 May-Jun Vol. 28 Issue 3 Pg. 244-246 ISSN: 0971-4065 [Print] India
• PMID: 29962679 (Publication Type: Case Reports)