A case of human leukocyte antigen B-27-associated ocular hypotony successfully treated with golimumab.

Abstract

A 42-year-old male presented to us after an episode of acute anterior human leukocyte antigen (HLA)-B27-associated uveitis, and intraocular pressure (IOP) in the right eye was 4 mmHg. Ultrasound biomicroscopy revealed ciliary body edema with supraciliary effusion. He was on a frequent topical corticosteroid, and oral steroid in addition to receiving a periocular injection depot corticosteroid 20 days back. He was started on treatment with subcutaneous golimumab (GLM). After a month, his IOP in the right eye was 14 mm of Hg with UBM showing resolution of ciliary body edema. GLM can be useful in the management of steroid-resistant cases of HLA B-27-associated ocular hypotony.

• Authors: Parthopratim Dutta Majumder, Ruchika Lakra, G Yamuna, Anindya Kishore Majumder, Viswanath Kaushik
• Journal: Indian journal of ophthalmology (Indian J Ophthalmol) Vol. 66 Issue 7 Pg. 1006-1008 (07 2018) ISSN: 1998-3689 [Electronic] India
• PMID: 29941755 (Publication Type: Case Reports)

Chemical References

• Antibodies, Monoclonal
• HLA-B27 Antigen
• golimumab

Topics

• Adult
• Antibodies, Monoclonal (administration & dosage)
• Ciliary Body (diagnostic imaging)
• HLA-B27 Antigen (immunology)
• Humans
• Injections, Subcutaneous
• Intraocular Pressure (physiology)
• Male
• Microscopy, Acoustic
• Ocular Hypotension (drug therapy, immunology, physiopathology)
• Tonometry, Ocular