Abstract | OBJECTIVES: BACKGROUND: METHODS: The multicenter PARTNER 2 (Placement of Aortic Transcatheter Valves) VIV trial enrolled patients with symptomatic degenerated surgical aortic bioprostheses who were at high risk for reoperation. Outcomes were assessed between patients with mild or no TR versus moderate or severe TR. RESULTS: A total of 237 patients underwent VIV procedures (mean age 78.7 ± 10.8 years, mean Society of Thoracic Surgeons score 9.1 ± 4.8%). In this cohort, 162 patients (68.4%) had mild or no TR, and 75 patients (31.6%) had moderate or severe TR. Although there was no difference in New York Heart Association functional class III or IV symptomatic status (89.3% vs. 91.4%; p = 0.62) or moderate or severe right ventricular dysfunction (9.4% vs. 16.9%; p = 0.11), patients with moderate or severe TR were more likely to be at high surgical risk, with a Society of Thoracic Surgeons score of >8 (62.7% vs 46.9%; p = 0.02). There was no difference in a composite endpoint of death and rehospitalization between moderate or severe TR and mild or no TR, either at 30 days (10.7% vs. 9.9%; p = 0.85) or at 1-year follow-up (24.1% vs. 23.2%; p = 0.80). There was a significant reduction in overall moderate or severe TR from baseline at 30 days (31.1% vs. 21.1%; p = 0.002), which was sustained at 1-year follow-up (38.0% vs. 22.8%; p = 0.004). CONCLUSIONS: Despite higher predicted surgical risk, the presence of TR was not a predictor of long-term outcomes. Importantly, there was significant reduction in TR severity at both short- and long-term follow-up. In selected patients undergoing VIV transcatheter aortic valve replacement, it may be appropriate to conservatively manage concomitant TR.
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Authors | Janarthanan Sathananthan, Dale J Murdoch, Brian R Lindman, Alan Zajarias, Wael A Jaber, Paul Cremer, David Wood, Robert Moss, Anson Cheung, Jian Ye, Rebecca T Hahn, Aaron Crowley, Martin B Leon, Michael J Mack, John G Webb |
Journal | JACC. Cardiovascular interventions
(JACC Cardiovasc Interv)
Vol. 11
Issue 12
Pg. 1154-1160
(06 25 2018)
ISSN: 1876-7605 [Electronic] United States |
PMID | 29929637
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2018 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. |
Topics |
- Aged
- Aged, 80 and over
- Aortic Valve
(diagnostic imaging, physiopathology, surgery)
- Aortic Valve Stenosis
(diagnostic imaging, physiopathology, surgery)
- Bioprosthesis
- Female
- Heart Valve Prosthesis
- Heart Valve Prosthesis Implantation
(adverse effects, instrumentation)
- Humans
- Male
- Prosthesis Design
- Prosthesis Failure
- Recovery of Function
- Registries
- Risk Factors
- Severity of Illness Index
- Time Factors
- Transcatheter Aortic Valve Replacement
(adverse effects, instrumentation)
- Treatment Outcome
- Tricuspid Valve Insufficiency
(diagnostic imaging, physiopathology, therapy)
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