Experimental Substantiation of Inhalation Administration of Pathogenic Therapy of Toxic Convulsive Disorder for Correction of External Respiration Disorders.

Abstract

We studied the dynamics of respiratory function in rats during intratracheal poisoning with diisopropyl fluorophosphate and pentylenetetrazole in doses corresponding to the LD50 in humans. The maximum of external respiration impairment was recorded in 30 min after poisoning. Administration of diazepam and atropine both separately and in combination during the development of the first signs of poisoning did not significantly affect the respiration parameters, but reduced the incidence of seizures and contributed to a decrease in the rate of animal death. Intratracheal administration of cholinolytic, β2-adrenomimetic, or glutamate receptors antagonist promoted correction of the respiratory function. It was found that the maximum therapeutic effect in case of diisopropyl fluorophosphates poisoning was achieved after intratracheal administration of ipratropium bromide (0.086 mg/kg), salbutamol (0.086 mg/kg), and MK-801 (0.1 mg/kg), while in case of pentylenetetrazole poisoning, intratracheal administration of ipratropium bromide (0.086 mg/kg) was most effective.

• Authors: N G Vengerovich, I M Drachkova, M A Yudin, V N Bykov, A M Sarana
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 165 Issue 2 Pg. 225-229 (Jun 2018) ISSN: 1573-8221 [Electronic] United States
• PMID: 29922996 (Publication Type: Journal Article)

Chemical References

• Bronchodilator Agents
• Convulsants
• Isoflurophate
• Atropine
• Ipratropium
• Diazepam
• Albuterol
• Pentylenetetrazole

Topics

• Administration, Inhalation
• Albuterol (administration & dosage)
• Animals
• Atropine (administration & dosage)
• Bronchodilator Agents (administration & dosage)
• Convulsants (poisoning)
• Diazepam (administration & dosage)
• Epilepsy (complications, drug therapy, pathology)
• Ipratropium (administration & dosage)
• Isoflurophate (poisoning)
• Male
• Pentylenetetrazole (poisoning)
• Rats
• Respiration Disorders (chemically induced, complications, drug therapy, pathology)
• Respiratory Mechanics (drug effects)
• Seizures (complications, drug therapy, pathology)