Abstract | WHAT WE ALREADY KNOW ABOUT THIS TOPIC: METHODS: A systematic search for randomized controlled trials was conducted using Ovid MEDLINE, PubMed, EMBASE, Cochrane Library, and Google search using the keywords processed electroencephalogram, Bispectral Index, postoperative delirium, postoperative cognitive dysfunction. Screening and data extraction were conducted by two independent reviewers, and risk of bias was assessed. Postoperative delirium combined-effect estimates calculated with a fixed-effects model were expressed as odds ratios with 95% CIs. RESULTS: Thirteen of 369 search results met inclusion criteria. Postoperative cognitive dysfunction data were excluded in meta-analysis because of heterogeneity of outcome measurements; results were discussed descriptively. Five studies were included in the quantitative postoperative delirium analysis, with data pooled from 2,654 patients. The risk of bias was low in three studies and unclear for the other two. The use of processed electroencephalogram-guided anesthesia was associated with a 38% reduction in odds for developing postoperative delirium (odds ratio = 0.62; P < 0.001; 95% CI, 0.51 to 0.76). CONCLUSIONS:
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Authors | Kristen K MacKenzie, Angelitta M Britt-Spells, Laura P Sands, Jacqueline M Leung |
Journal | Anesthesiology
(Anesthesiology)
Vol. 129
Issue 3
Pg. 417-427
(09 2018)
ISSN: 1528-1175 [Electronic] United States |
PMID | 29912008
(Publication Type: Journal Article, Meta-Analysis, Research Support, N.I.H., Extramural, Systematic Review)
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Topics |
- Anesthesia, General
(adverse effects)
- Electroencephalography
(methods)
- Emergence Delirium
(diagnosis, etiology, physiopathology)
- Humans
- Monitoring, Intraoperative
(methods)
- Randomized Controlled Trials as Topic
(methods)
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