Association Between CHEK2*1100delC and Breast Cancer: A Systematic Review and Meta-Analysis.

Abstract

INTRODUCTION:

The association between the checkpoint kinase 2*1100delC (CHEK2*1100delC) and breast cancer has been extensively explored.

OBJECTIVE:

In light of the recent publication of studies on these specific findings, particularly regarding male patients with breast cancer, we performed an updated meta-analysis to investigate a more reliable estimate.

METHODS:

This meta-analysis included 26 published studies selected in a search of electronic databases up to January 2018, including 118,735 breast cancer cases and 195,807 controls. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association between 1100delC and breast cancer.

RESULTS:

Meta-analysis results suggested that 1100delC contributed to an increased breast cancer risk in overall populations (OR 2.89; 95% CI 2.63-3.16). Subgroup analysis found ORs of 3.13 (95% CI 1.94-5.07) for male breast cancer, 2.88 (95% CI 2.63-3.16) for female breast cancer, 2.87 (95% CI 1.85-4.47) for early-onset breast cancer, 2.92 (95% CI 2.65-3.22) for invasive breast cancer, and 3.21 (95% CI 2.41-4.29) for familial breast cancer. The sensitivity analysis suggested that results of this meta-analysis were generally robust.

CONCLUSION:

CHEK2*1100delC is associated with an increased risk of both female and male breast cancer.

• Authors: Mingming Liang, Yun Zhang, Chenyu Sun, Feras Kamel Rizeq, Min Min, Tingting Shi, Yehuan Sun
• Journal: Molecular diagnosis & therapy (Mol Diagn Ther) Vol. 22 Issue 4 Pg. 397-407 (08 2018) ISSN: 1179-2000 [Electronic] New Zealand
• PMID: 29909568 (Publication Type: Journal Article, Meta-Analysis, Systematic Review)

Chemical References

• Biomarkers, Tumor
• Checkpoint Kinase 2
• CHEK2 protein, human

Topics

• Alleles
• Biomarkers, Tumor
• Breast Neoplasms (etiology, metabolism, pathology)
• Case-Control Studies
• Checkpoint Kinase 2 (genetics)
• Female
• Genetic Association Studies
• Genetic Predisposition to Disease
• Genotype
• Heterozygote
• Humans
• Male
• Odds Ratio
• Publication Bias
• Risk Assessment
• Risk Factors
• Sequence Deletion