An Extensive Study of the Functional Polymorphisms of Kinin-Kallikrein System in Rheumatoid Arthritis Susceptibility.

Abstract

OBJECTIVES:

This study aims to examine the following functional polymorphisms in rheumatoid arthritis (RA) susceptibility: (i) the 587C>T of kininogen gene, (ii) the 287 bp Alu repeat insertion of angiotensin converting enzyme gene, (iii) the 9 bp insertion of bradykinin receptor 2 gene, (iv) the -58T>C of bradykinin receptor 2 gene, and (v) the -699G>C of bradykinin receptor 1 gene.

PATIENTS AND METHODS:

The study included 136 RA patients (27 males; 109 females; mean age 60.8 years; range 39 to 75 years) and 149 ethnic matching controls (30 males, 119 females; mean age 56.2 years; range 35 to 78 years). Polymerase chain reaction coupled with restriction assay was performed for 587C>T, -58T>C, and -699G>C.

RESULTS:

Rheumatoid arthritis patients and controls carried the wild type allele of 587C>T; therefore, produced the high molecular weight kininogen. No significant difference was observed in genotype or allele distribution of the studied functional polymorphisms between RA patients and controls.

CONCLUSION:

Kinin-kallikrein system related genes might not be major RA susceptibility loci.

• Authors: Anthoula Chatzikyriakidou, Paraskevi V Voulgari, Alexandros A Drosos
• Journal: Archives of rheumatology (Arch Rheumatol) Vol. 33 Issue 1 Pg. 33-38 (Mar 2018) ISSN: 2148-5046 [Print] Turkey
• PMID: 29901003 (Publication Type: Journal Article)