Abstract | BACKGROUND: METHODS: Patients with stage III, IVA, or IVB LAHNSCC were enrolled in this study to evaluate the efficacy of S-1 compared with UFT as adjuvant chemotherapy after curative CRT in the ACTS-HNC study. Patients received S-1 at 80-120 mg/day in two divided doses for 2 weeks, followed by a 1-week rest, or UFT 300 or 400 mg/day in two or three divided doses daily, for 1 year. The endpoints were OS, disease-free survival, locoregional relapse-free survival, distant metastasis-free survival (DMFS), and post-locoregional relapse survival. RESULTS: One hundred eighty patients (S-1, n = 87; UFT, n = 93) were included in this study. Clinical characteristics of the S-1 and UFT arms were similar. S-1 after CRT significantly improved OS (hazard ratio [HR], 0.46; 95% confidence interval [CI], 0.22-0.93) and DMFS (HR, 0.50; 95% CI, 0.26-0.97) compared with UFT. CONCLUSION: As adjuvant chemotherapy, S-1 demonstrated better efficacy for OS and DMFS than UFT in patients with LAHNSCC after curative CRT and may be considered a treatment option following curative CRT. For this study was not preplanned in the ACTS-HNC study, the results is hypothesis generating but not definitive.
|
Authors | Akira Kubota, Eiji Nakatani, Kiyoaki Tsukahara, Yasuhisa Hasegawa, Hideki Takemura, Tomonori Terada, Takahide Taguchi, Kunihiko Nagahara, Hiroaki Nakatani, Kunitoshi Yoshino, Yuichiro Higaki, Shigemichi Iwae, Takeshi Beppu, Yutaka Hanamure, Kichinobu Tomita, Naoyuki Kohno, Kazuyoshi Kawabata, Satoshi Teramukai, Masato Fujii, ACTS-HNC Study Group |
Journal | PloS one
(PLoS One)
Vol. 13
Issue 6
Pg. e0198391
( 2018)
ISSN: 1932-6203 [Electronic] United States |
PMID | 29883463
(Publication Type: Clinical Trial, Phase III, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antimetabolites, Antineoplastic
- Drug Combinations
- S 1 (combination)
- Tegafur
- Uracil
- Oxonic Acid
|
Topics |
- Adult
- Aged
- Antimetabolites, Antineoplastic
(administration & dosage, therapeutic use)
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage, therapeutic use)
- Chemoradiotherapy
- Chemotherapy, Adjuvant
- Disease-Free Survival
- Drug Administration Schedule
- Drug Combinations
- Female
- Head and Neck Neoplasms
(drug therapy, pathology)
- Humans
- Male
- Middle Aged
- Neoplasm Staging
- Oxonic Acid
(administration & dosage, therapeutic use)
- Squamous Cell Carcinoma of Head and Neck
(drug therapy, pathology)
- Tegafur
(administration & dosage, therapeutic use)
- Treatment Outcome
- Uracil
(administration & dosage, therapeutic use)
|
|
Join CureHunter, for free Research Interface BASIC access!
Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease.
Find out why thousands of doctors, pharma researchers and patient activists
around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!
|