Botulinum toxin for hereditary spastic paraplegia: effects on motor and non-motor manifestations.

Abstract

Motor and non-motor manifestations are common and disabling features of hereditary spastic paraplegia (HSP). Botulinum toxin type A (Btx-A) is considered effective for spasticity and may improve gait in these patients. Little is known about the effects of Btx-A on non-motor symptoms in HSP patients. Objective To assess the efficacy of Btx-A on motor and non-motor manifestations in HSP patients. Methods Thirty-three adult patients with a clinical and molecular diagnosis of HSP were evaluated before and after Btx-A injections. Results Mean age was 41.7 ± 13.6 years and there were 18 women. Most patients had a pure phenotype and SPG4 was the most frequent genotype. The Btx-A injections resulted in a decrease in spasticity at the adductor muscles, and no other motor measure was significantly modified. In contrast, fatigue scores were significantly reduced after Btx-A injections. Conclusion Btx-A injections resulted in no significant functional motor improvement for HSP, but fatigue improved after treatment.

• Authors: Katiane R Servelhere, Ingrid Faber, Alberto Martinez, Renato Nickel, Adriana Moro, Francisco M B Germiniani, Mariana Moscovich, Tatiane R Blume, Renato P Munhoz, Hélio A G Teive, Marcondes C França Jr
• Journal: Arquivos de neuro-psiquiatria (Arq Neuropsiquiatr) Vol. 76 Issue 3 Pg. 183-188 (Mar 2018) ISSN: 1678-4227 [Electronic] Germany
• PMID: 29809239 (Publication Type: Evaluation Study, Journal Article, Multicenter Study)

Chemical References

• Neuromuscular Agents
• Botulinum Toxins, Type A

Topics

• Adult
• Age of Onset
• Botulinum Toxins, Type A (therapeutic use)
• Female
• Gait (drug effects, physiology)
• Humans
• Injections, Intramuscular
• Male
• Middle Aged
• Motor Disorders (drug therapy, physiopathology)
• Muscle Fatigue (drug effects, physiology)
• Muscle Spasticity (drug therapy, physiopathology)
• Neuromuscular Agents (therapeutic use)
• Reproducibility of Results
• Spastic Paraplegia, Hereditary (drug therapy, physiopathology)
• Treatment Outcome