Studies on Steroid Receptor Coactivators in Prostate Cancer.

Abstract

High expression of several androgen receptor coactivators is frequently reported in prostate cancer. Coactivators such as p300/CBP are involved in modulation of androgen receptor activity by increasing the effects of androgenic hormones and enhancing agonistic activity of antiandrogens. Studies in the field of prostate cancer frequently examined the role of p300/CBP and SRC-1 (NCOA1). In addition to their effects on steroid receptor activity, coactivators may influence other cellular functions such as migration and invasion. Steroid receptor coactivators may target various downstream genes, thus modulating proliferative and migratory responses in specific prostate cancer models. This chapter will focus on methodologies used to analyze the role of steroid receptor coactivators in prostate cancer.

• Authors: Zoran Culig, Frédéric R Santer
• Journal: Methods in molecular biology (Clifton, N.J.) (Methods Mol Biol) Vol. 1786 Pg. 259-262 ( 2018) ISSN: 1940-6029 [Electronic] United States
• PMID: 29786798 (Publication Type: Journal Article)

Chemical References

• Receptors, Androgen
• Receptors, Steroid

Topics

• Cell Line, Tumor
• Cell Movement (genetics)
• Cell Proliferation (genetics)
• Gene Knockdown Techniques
• HEK293 Cells
• Humans
• Male
• Prostatic Neoplasms (metabolism)
• Receptors, Androgen (metabolism)
• Receptors, Steroid (metabolism)