Abstract | BACKGROUND: OBJECTIVES: To perform a systematic review and meta-analysis to compare the effectiveness of these quite different treatment approaches, especially on relapse rates (RRs) after achieving remission. METHODS: Published studies that included follow-up for at least 1 year after treatment of PCT were included. The primary study outcome was PCT relapse. Pooled data are reported as the RRs per person-year of follow-up with 95% confidence intervals (CIs). RESULTS: Of 375 articles identified as pertaining to PCT treatment, 12 were eligible for analysis. Of these, five used high-dose 4-aminoquinoline regimens (two combined with phlebotomy and three without phlebotomy), five used low-dose 4-aminoquinoline regimens and three used phlebotomy. RRs during the year after treatment were similar for the high- and low-dose 4-aminoquinoline groups (35-36%) and lower in the phlebotomy group (20%). The pooled RRs with their 95% CIs were 8·6 (3·9-13·3) per 100 person-years in the high-dose 4-aminoquinoline group, 17·1 (8·9-25·3) per 100 person-years in the low-dose 4-aminoquinoline group and 5·1 (0·5-10·6) per 100 person-years in the phlebotomy group. Subgroup and sensitivity analyses showed similar results. CONCLUSIONS: Clinical or biochemical RRs ranged from 5 to 17 per 100 person-years after remission of PCT. Relapses were somewhat more frequent after remission with 4-aminoquinoline regimens than after remission following phlebotomy. Prospective studies are needed to define better how often relapses occur with these treatments after documenting both clinical and biochemical remission of PCT.
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Authors | H Salameh, H Sarairah, M Rizwan, Y-F Kuo, K E Anderson, A K Singal |
Journal | The British journal of dermatology
(Br J Dermatol)
Vol. 179
Issue 6
Pg. 1351-1357
(12 2018)
ISSN: 1365-2133 [Electronic] England |
PMID | 29750336
(Publication Type: Journal Article, Meta-Analysis, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Systematic Review)
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Copyright | © 2018 British Association of Dermatologists. |
Chemical References |
- Aminoquinolines
- Antimalarials
- 4-aminoquinoline
|
Topics |
- Aminoquinolines
(administration & dosage)
- Antimalarials
(administration & dosage)
- Dose-Response Relationship, Drug
- Humans
- Phlebotomy
- Porphyria Cutanea Tarda
(therapy)
- Recurrence
- Treatment Outcome
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