Abstract | BACKGROUND: METHODS: Twelve patients with refractory DSM-IV generalized anxiety disorder and/or social anxiety disorder provided EEG during 10 minutes of relaxation before and 2 hours after receiving double-blind drug administration. Three ascending ketamine dose levels (0.25, 0.5, and 1 mg/kg) and midazolam (0.01 mg/kg) were given at 1-week intervals to each patient, with the midazolam counterbalanced in dosing position across patients. Anxiety was assessed pre- and postdose with the Fear Questionnaire and HAM-A. RESULTS:
Ketamine dose-dependently improved Fear Questionnaire but not HAM-A scores, decreased EEG power most at low (delta) frequency, and increased it most at high (gamma) frequency. Only the decrease in medium-low (theta) frequency at right frontal sites predicted the effect of ketamine on the Fear Questionnaire. Ketamine produced no improvement in Higuchi's fractal dimension at any dose or systematic changes in frontal alpha asymmetry. CONCLUSIONS:
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Authors | Shabah Mohammad Shadli, Tame Kawe, Daniel Martin, Neil McNaughton, Shona Neehoff, Paul Glue |
Journal | The international journal of neuropsychopharmacology
(Int J Neuropsychopharmacol)
Vol. 21
Issue 8
Pg. 717-724
(08 01 2018)
ISSN: 1469-5111 [Electronic] England |
PMID | 29718262
(Publication Type: Journal Article)
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Copyright | © The Author(s) 2018. Published by Oxford University Press on behalf of CINP. |
Chemical References |
- Anti-Anxiety Agents
- Ketamine
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Topics |
- Adolescent
- Adult
- Aged
- Anti-Anxiety Agents
(adverse effects, therapeutic use)
- Anxiety
(diagnosis, physiopathology, psychology)
- Brain
(drug effects, physiopathology)
- Dose-Response Relationship, Drug
- Double-Blind Method
- Drug Resistance
- Electrocardiography
- Fear
(drug effects)
- Female
- Humans
- Ketamine
(adverse effects, therapeutic use)
- Male
- Middle Aged
- Phobia, Social
(diagnosis, psychology, therapy)
- Predictive Value of Tests
- Time Factors
- Treatment Outcome
- Young Adult
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