Abstract | BACKGROUND: Limited data exist regarding the long-term association of body mass index (BMI) and all-cause mortality among patients with stable coronary artery disease (CAD). Accordingly, the aim of this study is to explore the association between BMI and long-term all-cause mortality among patients with stable CAD. METHODS: Our study included 15,357 patients with stable CAD who were enrolled in the Bezafibrate Infarction Prevention (BIP) registry between February, 1990 and October1992, and subsequently followed-up through December 2014. RESULTS: 5,051 (33%) patients were classified as normal weight (BMI 18.5-24.99kg/m2), while 7,841 (51%) patients were classified as overweight (BMI 25-29.99kg/m2), and 2,465 (16%) as obese (BMI≥30). Kaplan-Meier survival analysis showed that at 20 years of follow-up the rate of all-cause mortality was significantly higher among obese patients (67%) compared to overweight (61%) and normal weight (61%); log rank p-value for the overall difference <0.001. Multivariable analysis showed that obese patients had an independently 12% greater mortality risk compared to normal weight patients (HR=1.12; 95% CI 1.02-1.23; p=0.02), whereas, overweight patients experienced a similar mortality risk as normal weight patients (HR=0.99; 95% CI 0.92-1.06; p=0.76). The mortality risk associated with obesity was pronounced among patients younger than 65 years (p-value for interaction<0.05). CONCLUSIONS: Our findings indicate that obesity is independently associated with increased risk for long-term mortality among patients with stable coronary artery disease, whereas overweight does not appear to confer an additional risk in this population.
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Authors | Anan Younis, Arwa Younis, Ronen Goldkorn, Ilan Goldenberg, Yael Peled, Boaz Tzur, Robert Klempfner |
Journal | Heart, lung & circulation
(Heart Lung Circ)
Vol. 28
Issue 5
Pg. 719-726
(May 2019)
ISSN: 1444-2892 [Electronic] Australia |
PMID | 29581037
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)
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Copyright | Copyright © 2018 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved. |
Chemical References |
- Hypolipidemic Agents
- Bezafibrate
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Topics |
- Bezafibrate
(therapeutic use)
- Body Mass Index
- Cause of Death
(trends)
- Coronary Artery Disease
(etiology, mortality, prevention & control)
- Female
- Follow-Up Studies
- Forecasting
- Humans
- Hypolipidemic Agents
(therapeutic use)
- Israel
(epidemiology)
- Male
- Middle Aged
- Obesity
(complications, epidemiology, physiopathology)
- Population Surveillance
- Prospective Studies
- Registries
- Survival Rate
(trends)
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