Experimental Analysis of the Efficacy of Dihydroquercetin on the Model of Chronic Nonbacterial Inflammation of the Prostatic Gland.

Abstract

We studied the efficiency of dihydroquercetin on the model of chronic nonbacterial inflammation of the prostatic gland in rats. It was found that administration of dihydroquercetin was followed by a significant decrease in the area of the connective tissue in the prostatic gland to initial levels, which attested to antifibrotic properties of this oxidant. Additionally, the substance prevented the development of atrophy of acinus epithelium. After administration of reference drug Prostamol Uno, only moderate antifibrotic effects were observed.

• Authors: T G Borovskaya, S I Kamalova, M E Polyektova, V A Mashanova, A V Vychuzhanina, S I Kseneva, M B Plotnikov, V E Goldberg
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 164 Issue 5 Pg. 617-619 (Mar 2018) ISSN: 1573-8221 [Electronic] United States
• PMID: 29577199 (Publication Type: Journal Article)

Chemical References

• Quercetin
• taxifolin

Topics

• Animals
• Chronic Disease
• Inflammation (immunology, pathology)
• Male
• Prostate (drug effects, immunology, pathology)
• Prostatitis (drug therapy, immunology)
• Quercetin (analogs & derivatives, therapeutic use)
• Rats
• Rats, Wistar