[Drug risk of hepatic porphyria. Development of an animal experiment model].

Abstract

Hepatic porphyrias (acute intermittent porphyria, coproporphyria, porphyria variegata and porphyria cutanea) are inherited diseases affecting porphyrin-heme metabolism in the liver. A situation analogous to the latent stage of human hepatic porphyria can be produced in chick embryos by injecting an inhibitor of ferrochelatase (the last enzyme in the heme biosynthesis pathway); the simultaneous injection of a porphyrinogenic drug (e.g. barbiturate) results in a strong increase of liver porphyrin levels, as is found in human hepatic porphyrias. This experimental model facilitates drug screening: drugs that are found to be porphyrinogenic in ovo are potentially dangerous to patients with hepatic porphyria and should be avoided.

• Authors: J C Deybach, V Da Silva, L N Phung, J C Levy, Y Nordmann
• Journal: Presse medicale (Paris, France : 1983) (Presse Med) Vol. 16 Issue 2 Pg. 68-71 (Jan 24 1987) ISSN: 0755-4982 [Print] France
• Vernacular Title: Le risque médicamenteux des porphyries hépatiques. Mise en place d'un modèle animal expérimental.
• PMID: 2949310 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Porphyrinogens

Topics

• Animals
• Chemical and Drug Induced Liver Injury
• Chick Embryo
• Disease Models, Animal
• Porphyrias (chemically induced)
• Porphyrinogens