Despite lots of research on the pathogenesis of
acne, the development of new therapeutic agents is still stagnant. Conventional agents which target multiple
pathological processes have some serious side effects and this makes seeking new treatment options important for treating
acne. As new therapeutic options, researchers are focusing on natural products,
synthetic drugs and devices. From natural products, epigallocatechin-3 gallate,
lupeol,
cannabidiol and Lactobacillus fermented Chamaecyperis obtusa were reported to be possible candidates for novel drugs, targeting multiple pathogenic factors. Synthetic anti-P.acnes agent,
nitric oxide nanoparticles and α-
mangostin nanoparticles are shown to be effective in
acne treatment. Device or procedural methods such as fractional
microneedling radiofrequency, cryolysis, photothermolysis and daylight
photodynamic therapy have potential as new treatment options for
acne. Further large clinical trials comparing these new treatments with existing agents will be necessary in the future.