Nonylphenol aggravates non-alcoholic fatty liver disease in high sucrose-high fat diet-treated rats.

Abstract

Exposure to environmental endocrine disruptors (EEDs) contributes to the pathogenesis of many metabolic disorders. Here, we have analyzed the effect of the EED-nonylphenol (NP) on the promotion of non-alcoholic fatty liver disease (NAFLD) in rats fed high sucrose-high fat diet (HSHFD). Fifty Sprague-Dawley rats were divided into five groups: controls fed a normal diet (C-ND); HSHFD-fed controls (C-HSHFD); and rats fed a HSHFD combined with NP at doses of 0.02 μg/kg/day (NP-L-HSHFD), 0.2 μg/kg/day (NP-M-HSHFD), and 2 μg/kg/day (NP-H-HSHFD). Subchronic exposure to NP coupled with HSHFD increased daily water and food intake (p < 0.05), hepatic echogenicity and oblique liver diameter (p < 0.05), and plasma levels of alanine aminotransferase, aspartate aminotransferase, total cholesterol, triglycerides, and low density lipoprotein cholesterol (p < 0.05). Combined exposure to NP and HSHFD induced macrovesicular steatosis with dilation and congestion of the central vein, liver inflammatory cell infiltration, and expression of genes regulating lipid metabolism, SREBP-1C, FAS, and Ucp2. These results demonstrate that NP aggravates NAFLD in HSHFD-treated rats by up-regulating lipogenic genes, and that HSHFD increases the toxic effects of NP. Thus subchronic NP exposure may lead to NAFLD, especially when combined with a high-sucrose/high-fat diet.

• Authors: Jie Yu, Xuesong Yang, Xuefeng Yang, Mengxue Yang, Pan Wang, Yu Yang, Jing Yang, Wenmei Li, Jie Xu
• Journal: Scientific reports (Sci Rep) Vol. 8 Issue 1 Pg. 3232 (02 19 2018) ISSN: 2045-2322 [Electronic] England
• PMID: 29459774 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Endocrine Disruptors
• Environmental Pollutants
• Fats
• Lipoproteins, LDL
• Phenols
• Triglycerides
• Sucrose
• nonylphenol
• Cholesterol
• Aspartate Aminotransferases
• Alanine Transaminase

Topics

• Alanine Transaminase (blood)
• Animals
• Aspartate Aminotransferases (blood)
• Blood Chemical Analysis
• Cholesterol (blood)
• Diet (methods)
• Endocrine Disruptors (toxicity)
• Environmental Pollutants (toxicity)
• Fats (administration & dosage)
• Fatty Liver (pathology)
• Lipoproteins, LDL (blood)
• Liver (pathology)
• Non-alcoholic Fatty Liver Disease (pathology)
• Phenols (toxicity)
• Rats, Sprague-Dawley
• Sucrose (administration & dosage)
• Triglycerides (blood)