Association between acute respiratory disease events and the MUC5B promoter polymorphism in smokers.

Abstract

A single-nucleotide polymorphism (rs35705950) in the mucin 5B (MUC5B) gene promoter is associated with pulmonary fibrosis and interstitial features on chest CT but may also have beneficial effects. In non-Hispanic whites in the COPDGene cohort with interstitial features (n=454), the MUC5B promoter polymorphism was associated with a 61% lower odds of a prospectively reported acute respiratory disease event (P=0.001), a longer time-to-first event (HR=0.57; P=0.006) and 40% fewer events (P=0.016). The MUC5B promoter polymorphism may have a beneficial effect on the risk of acute respiratory disease events in smokers with interstitial CT features.

• Authors: Samuel Y Ash, Rola Harmouche, Rachel K Putman, James C Ross, Fernando J Martinez, Augustine M Choi, Russell P Bowler, Elizabeth A Regan, Jeffrey L Curtis, MeiLan K Han, Richard C Boucher, Wanda K O'Neal, Hiroto Hatabu, David A Lynch, Ivan O Rosas, Gary M Hunninghake, Raul San Jose Estepar, George R Washko, COPDGene Investigators
• Journal: Thorax (Thorax) Vol. 73 Issue 11 Pg. 1071-1074 (11 2018) ISSN: 1468-3296 [Electronic] England
• PMID: 29440587 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
• Copyright: © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Chemical References

• MUC5B protein, human
• Mucin-5B
• DNA

Topics

• Acute Disease
• DNA (genetics)
• Female
• Genetic Predisposition to Disease
• Genotype
• Humans
• Mucin-5B (genetics, metabolism)
• Polymorphism, Single Nucleotide
• Promoter Regions, Genetic
• Respiratory Tract Diseases (etiology, genetics, metabolism)
• Smokers
• Smoking (adverse effects)