The Safety and Efficacy of Treatment with Nab-paclitaxel and Carboplatin for Patients with Advanced Squamous Non-small Cell Lung Cancer Concurrent with Idiopathic Interstitial Pneumonias.

Abstract

Objective Although lung squamous cell carcinoma (SCC) accounts for 20-30% of lung cancer cases, new treatment options are limited. The CA031 study showed that nanoparticle albumin-bound-paclitaxel (nab-PTX) plus carboplatin produced a significantly higher overall response rate (41%) than solvent-based paclitaxel plus carboplatin in patients with lung SCC. However, the safety and efficacy of combination chemotherapy of nab-PTX and carboplatin has not yet been established for patients with concurrent lung SCC and idiopathic interstitial pneumonias (IIPs). The aim of this study was to assess the safety and efficacy profiles of nab-PTX and carboplatin in patients with lung SCC and concurrent IIPs. Methods Eight patients with inoperable-stage lung SCC and IIPs were treated with nab-PTX plus carboplatin in a first-line setting between June 2013 and December 2016. One of the eight was a woman, and the median age was 77 (range=72-80) years. Their clinical outcomes, including chemotherapy-associated acute exacerbation of IIPs, were retrospectively investigated. Results The overall response rate was 50%, the median progression-free survival time was 5.6 months, and the median overall survival time was 8.1 months. No patients experienced chemotherapy-related exacerbation of IIPs in the first-line treatment with nab-PTX plus carboplatin. However, IIPs worsened in two of four patients who received second-line chemotherapy. Conclusion Combination chemotherapy of nab-PTX and carboplatin may be an effective and safe treatment option for patients with inoperable lung SCC with IIPs. To confirm this, a large-scale prospective study is needed.

• Authors: Tetsuo Fujita, Takuma Hiroishi, Kohei Shikano, Asako Yanagisawa, Noriko Hayama, Hiroyuki Amano, Makoto Nakamura, Satoshi Hirano, Hiroshi Tabeta, Sukeyuki Nakamura
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 57 Issue 13 Pg. 1827-1832 (Jul 01 2018) ISSN: 1349-7235 [Electronic] Japan
• PMID: 29434143 (Publication Type: Journal Article)

Chemical References

• 130-nm albumin-bound paclitaxel
• Albumins
• Carboplatin
• Paclitaxel

Topics

• Aged
• Aged, 80 and over
• Albumins (therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Carboplatin (therapeutic use)
• Carcinoma, Non-Small-Cell Lung (drug therapy, physiopathology)
• Carcinoma, Squamous Cell (drug therapy)
• Comorbidity
• Female
• Humans
• Idiopathic Interstitial Pneumonias (physiopathology)
• Lung Neoplasms (drug therapy, physiopathology)
• Male
• Paclitaxel (therapeutic use)
• Prospective Studies
• Retrospective Studies