The Sex Influence on Response to Tumor Necrosis Factor-α Inhibitors and Remission in Axial Spondyloarthritis.

Abstract

OBJECTIVE:

The aim of this study was to evaluate the influence of sex on response to treatment and disease remission in patients with axial spondyloarthritis (axSpA).

METHODS:

In this retrospective multicenter study, patients with axSpA, according to the Assessment of Spondyloarthritis international Society (ASAS) criteria for axSpA, and treated with adalimumab, etanercept, golimumab, or infliximab, were studied. We compared clinical characteristics, patient-reported outcomes, disease activity, function, and response to treatment in male and female patients with this disease.

RESULTS:

Three hundred forty patients with axSpA (270 with ankylosing spondylitis, 19 with psoriatic arthritis with axial involvement, and 51 with nonradiographic axSpA) were studied. Male subjects had a significantly higher prevalence of grade IV sacroiliitis, higher levels of serum C-reactive protein, lower Maastricht Ankylosing Spondylitis Enthesitis Score, and fatigue when compared with females. Further, Kaplan-Meier survival curves showed that the rate of partial remission, ASAS40 response, and Ankylosing Spondylitis Disease Activity Score (ASDAS) major improvement, but not ASDAS inactive disease, were significantly lower in female patients.

CONCLUSION:

Our data suggest that female sex was associated with a lower rate of response to treatment and of disease remission in patients with axSpA treated with antitumor necrosis factor-α drugs.

• Authors: Ennio Lubrano, Fabio Massimo Perrotta, Maria Manara, Salvatore D'Angelo, Olga Addimanda, Roberta Ramonda, Leonardo Punzi, Ignazio Olivieri, Carlo Salvarani, Antonio Marchesoni
• Journal: The Journal of rheumatology (J Rheumatol) Vol. 45 Issue 2 Pg. 195-201 (02 2018) ISSN: 0315-162X [Print] Canada
• PMID: 29419448 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Monoclonal
• Antirheumatic Agents
• Tumor Necrosis Factor-alpha
• C-Reactive Protein
• Etanercept

Topics

• Adult
• Antibodies, Monoclonal (administration & dosage, pharmacology, therapeutic use)
• Antirheumatic Agents (administration & dosage, pharmacology, therapeutic use)
• C-Reactive Protein (analysis)
• Chi-Square Distribution
• Etanercept (administration & dosage, pharmacology, therapeutic use)
• Female
• Follow-Up Studies
• Humans
• Kaplan-Meier Estimate
• Logistic Models
• Male
• Middle Aged
• Multivariate Analysis
• Patient Reported Outcome Measures
• Remission Induction
• Retrospective Studies
• Sacroiliitis (pathology)
• Severity of Illness Index
• Sex Factors
• Spondylitis, Ankylosing (drug therapy)
• Statistics, Nonparametric
• Treatment Outcome
• Tumor Necrosis Factor-alpha (antagonists & inhibitors)