Abstract | BACKGROUND: OBJECTIVES: ANIMALS: Two hundred and sixty-two hyperthyroid cats and 206 aged-matched, clinically normal cats. METHODS: Prospective study. We measured creatinine, urea nitrogen, SDMA, T4 , and TSH concentrations before and 1, 3, and 6 months after treatment with radioiodine (131 I) and classified 131 I-treated cats as azotemic or nonazotemic based on persistent, post-treatment creatinine concentrations >2.1 mg/dL. Groups were compared via nonparametric tests, and diagnostic accuracy was determined by receiver operating characteristic analysis and logistic regression. RESULTS: No hyperthyroid cats were azotemic before treatment, but 42 (16%) became azotemic when rechecked at 4-8 months (median, 6 months) after 131 I treatment; of these, 14 had high SDMA concentrations before treatment. As a diagnostic test for pre-azotemic (masked) CKD in untreated hyperthyroid cats, SDMA showed a sensitivity of 33.3% and specificity of 97.7%. CONCLUSIONS AND CLINICAL IMPORTANCE: Finding a high serum SDMA concentration in a hyperthyroid cat can help predict development of azotemia after treatment. The test has high diagnostic test specificity (few false-positive results) but relatively low sensitivity (fails to predict azotemia in most hyperthyroid cats).
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Authors | M E Peterson, F V Varela, M Rishniw, D J Polzin |
Journal | Journal of veterinary internal medicine
(J Vet Intern Med)
Vol. 32
Issue 1
Pg. 295-304
(Jan 2018)
ISSN: 1939-1676 [Electronic] United States |
PMID | 29377360
(Publication Type: Journal Article)
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Copyright | Copyright © 2018 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine. |
Chemical References |
- Biomarkers
- symmetric dimethylarginine
- Arginine
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Topics |
- Animals
- Arginine
(analogs & derivatives, blood)
- Azotemia
(blood, diagnosis, veterinary)
- Biomarkers
(blood)
- Cat Diseases
(blood, diagnosis)
- Cats
- Female
- Glomerular Filtration Rate
- Hyperthyroidism
(blood, diagnosis, veterinary)
- Male
- Prospective Studies
- Renal Insufficiency, Chronic
(blood, diagnosis, veterinary)
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