Abstract | BACKGROUND: OBJECTIVE: ANIMALS: Sixteen weaned, apparently healthy, commercial beef calves from the University of Missouri, College of Veterinary Medicine teaching herd. METHODS: In vitro viral and bacterial assays were performed to determine susceptibility to the LPO/H2 O2 /I- system at varying concentrations of NaI. Sixteen randomly selected, healthy crossbred beef weanlings were administered 70 mg/kg NaI, or water, orally in a blinded, placebo-controlled trial. Blood and nasal secretions were collected for 72 hours and analyzed for I- concentration. RESULTS: Bovine herpesvirus-1, parainfluenza-3, Mannheimia haemolytica and Bibersteinia trehalosi were all inactivated or inhibited in vitro by the LPO/H2 O2 /I- reaction. Oral administration of NaI caused a marked increase in nasal fluid I concentration with a Cmax = 181 (1,420 μM I), T12 , a sufficient concentration to inactivate these pathogens in vitro. CONCLUSIONS AND CLINICAL IMPORTANCE: In vitro, the LPO/H2 O2 /I- system inactivates and inhibits common pathogens associated with BRD. The administration of oral NaI significantly increases the I concentration of nasal fluid indicating that this system might be useful in preventing bovine respiratory infections.
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Authors | B M Shoemake, B L Vander Ley, B W Newcomer, M C Heller |
Journal | Journal of veterinary internal medicine
(J Vet Intern Med)
Vol. 32
Issue 1
Pg. 516-524
(Jan 2018)
ISSN: 1939-1676 [Electronic] United States |
PMID | 29377356
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | Copyright © 2018 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine. |
Chemical References |
- Iodine
- Hydrogen Peroxide
- Lactoperoxidase
- Sodium Iodide
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Topics |
- Administration, Oral
- Animals
- Bovine Respiratory Disease Complex
(microbiology, prevention & control, virology)
- Cattle
- Herpesvirus 1, Bovine
(drug effects)
- Hydrogen Peroxide
(chemistry)
- Iodine
(analysis)
- Lactoperoxidase
(metabolism)
- Mannheimia haemolytica
(drug effects)
- Nasal Mucosa
(chemistry, microbiology, virology)
- Parainfluenza Virus 3, Human
(drug effects)
- Pasteurellaceae
(drug effects)
- Sodium Iodide
(administration & dosage, analysis, pharmacology)
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