Early Relief of Pruritus in Atopic Dermatitis with Crisaborole Ointment, A Non-steroidal, Phosphodiesterase 4 Inhibitor.

Abstract

Pruritus occurs in all patients with atopic dermatitis and requires quick relief to reduce disease exacerbation and improve quality of life. Crisaborole ointment is a non-steroidal phosphodiesterase 4 inhibitor for the treatment of mild-to-moderate atopic dermatitis. This post hoc analysis explores crisaborole ointment for early relief of pruritus in patients with mild to moderate atopic dermatitis from 2 phase III studies. Patients received crisaborole or vehicle twice daily for 28 days. Pruritus was graded on a 4-point scale of none (0) to severe (3). Early improvement in pruritus required a score of none (0) or mild (1), with a ≥ 1-grade improvement from baseline on day 6. Significantly more patients experienced early improvement in pruritus with crisaborole than with vehicle (56.6% vs 39.5%; p< 0.001), including at earliest assessment (day 2, 34.3% vs 27.3%; p = 0.013). Crisaborole is a topical treatment option that can rapidly relieve atopic dermatitis-associated pruritus.

• Authors: Gil Yosipovitch, Linda F Gold, Mark G Lebwohl, Jonathan I Silverberg, Anna M Tallman, Lee T Zane
• Journal: Acta dermato-venereologica (Acta Derm Venereol) Vol. 98 Issue 5 Pg. 484-489 (Apr 27 2018) ISSN: 1651-2057 [Electronic] Sweden
• PMID: 29363715 (Publication Type: Clinical Trial, Phase III, Journal Article, Multicenter Study, Randomized Controlled Trial)

Chemical References

• Antipruritics
• Boron Compounds
• Ointments
• Phosphodiesterase 4 Inhibitors
• crisabolore

Topics

• Administration, Cutaneous
• Adolescent
• Adult
• Antipruritics (administration & dosage, adverse effects)
• Boron Compounds (administration & dosage, adverse effects)
• Child
• Child, Preschool
• Dermatitis, Atopic (diagnosis, drug therapy, immunology)
• Double-Blind Method
• Female
• Humans
• Male
• Ointments
• Phosphodiesterase 4 Inhibitors (administration & dosage, adverse effects)
• Pruritus (diagnosis, drug therapy, immunology)
• Remission Induction
• Time Factors
• Treatment Outcome